Alcohol is an organic compound that appears in a variety of forms. The ingestible form, for both legitimate and abuse purposes, is ethanol. It is and has been historically used for hygienic, dietary, medicinal, religious, and recreational purposes.

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Barbiturates are central nervous system (CNS) depressants with a wide range of effects and uses: mild sedation to total anesthesia, hypnotics, anticonvulsants (epilepsy), migraine treatment (in fioricet), capital punishment, and assisted suicide where legal.

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Because of its low opiate effect, buprenorphine has a lower potential for abuse than other opioid drugs, but it can still be abused through crushing of tablets for snorting or for injection preparations.

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Cocaine (benzoylmethylecgonine) is a crystalline alkaloid drug obtained from the leaves of the coca plant, native to South America, where the leaves are chewed as a mild stimulant.

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Fentanyl is a powerful synthetic opioid analgesic with a rapid onset and short duration of action. It can also be used in combination with benzodiazepines as an anesthetic.

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GHB is abused as an intoxicant, often in the club, rave and party scene, to produce euphoria and sociability. Small doses can act as a stimulant and aphrodisiac. It is also notorious for use as a date rape drug, although studies have indicated that it is not used as frequently for that purpose as other drugs, such as cocaine.

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K2 and Spice are common street names for synthetic marijuana, produced by combining artificial cannabinoids with traditionally used medicinal herbs and other legal substances.

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Ketamine is an anesthetic drug used in human and veterinary medicine, primarily for general anesthesia, although it is sometimes used as a sedative for seriously injured patients and as a painkiller in cases of extreme pain.

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